MalA

Enzyme Information
reference: 10.1021/jacs.7b06773
test: 1H NMR analysis
producer: Malbranchea graminicola
phmm-model: FDH_conventional.hmm

Gene Data
phmm effect mutation gene_name reference
- None Leu276 MalA DOI: 10.1021/jacs.7b06773
209 None W265 MalA DOI: 10.1021/jacs.7b06773
207 None W263 MalA DOI: 10.1021/jacs.7b06773
- selective for producing the C9- chlorinated malbrancheamide B H253A MalA DOI: 10.1021/jacs.7b06773
- selectivity for producing C8-chlorinated isomalbrancheamide B H253F MalA DOI: 10.1021/jacs.7b06773
- inactive K108A MalA DOI: 10.1021/jacs.7b06773
- inactive E494A MalA DOI: 10.1021/jacs.7b06773
- inactive E494Q MalA DOI: 10.1021/jacs.7b06773
- reduced activity compared to WT W263A MalA DOI: 10.1021/jacs.7b06773
- no isomalbrancheamide B conversion and very reduced activity for malbrancheamide and for malbrancheamide B W265A MalA DOI: 10.1021/jacs.7b06773
- very reduced activity compared to WT S409A MalA DOI: 10.1021/jacs.7b06773
- very reduced conversion of isomalbrancheamide B compared to WT F489H MalA DOI: 10.1021/jacs.7b06773
- no isomalbrancheamide B conversion, very reduced activity compared to WT E494D MalA DOI: 10.1021/jacs.7b06773
- no isomalbrancheamide B conversion, very reduced conversion of malbrancheamide and malbrancheamide B D109A MalA DOI: 10.1021/jacs.7b06773
- reduced activity compared to WT S129A MalA DOI: 10.1021/jacs.7b06773
- comparable activity for malbrancheamide and malbrancheamide B formation and very reduced activity for isomalbrancheamide B compared to WT S129A/H253F MalA DOI: 10.1021/jacs.7b06773
296 None S409 MalA DOI: 10.1021/jacs.7b06773
305 None R428 MalA DOI: 10.1021/jacs.7b06773
- None E494 MalA DOI: 10.1021/jacs.7b06773
344 None F489 MalA DOI: 10.1021/jacs.7b06773
30 None S82 MalA DOI: 10.1021/jacs.7b06773
57 None K108 MalA DOI: 10.1021/jacs.7b06773